Collagen

Collagen
Stimulating Collagen Production

According to Dr. Leslie Baumann’s Cosmetic Dermatology, collagen production decreases by approximately 1 percent with each year of age after maturity (about age 21), leading to a loss in firmness and elasticity of skin. So what’s an age-conscious woman to do? Here are some options to stimulating collagen production.

1. Lasers
Two recently developed lasers are the Genesis and Medlite lasers, which have been reported in the Annals of Plastic Surgery to stimulate skin to make new collagen. Genesis and Medlite lasers are only administered by licensed dermatologists. Most women require three to six treatments, and the results should last three to five years. According to the March 2008 issue of Health magazine, Genesis and Medlite laser treatments are about $400 each. Check with a dermatologist near you for pricing and availability.

2. Facial Light Therapy
According to a recent study featured in the March 2008 issue of Allure magazine, LED phototherapy repairs sun damage and increases collagen and elastin production, although “lasers and peels have faster, more substantial results, but more side effects,” according to Seung Yoon Lee, a dermatologist at the National Medical Center in South Korea. With regards to LED therapy’s fewer side effects, Lee adds, “LED is safe for dark skin, unlike some lasers.”

According to Allure magazine, in the study, the researchers treated one side of 61 subjects’ faces with a light-emitting diode machine, while 15 others received a one-sided placebo treatment. Twelve weeks later, only the LED-targeted skin had a decrease in wrinkles (26-36 percent) and an increase in elasticity (14-19 percent). LED therapy seems to increase collagen and elastin production, although less significantly than lasers and peels.

3. Retinoid Treatments According to research by Fisher et. al cited by Dr. Baumann in Cosmetic Dermatology, retinoids are effective in preventing and treating the collagen loss caused by photodamage. UV exposure decreases collagen type I and collagen type III with 24 hours, but treatment of the skin with all-trans retinoic acid prevents the loss of these types of collagen synthesis. In addition, Fisher et. al demonstrated that application of tretinoin inhibits the induction of matrix metalloproteinase genes, which are in part responsible for collagen degradation. Your best option is to talk to your dermatologist about prescription retinoid treatments.

4. Glycolic Acid Peels
According to a 1998 study in Dermatological Surgery, glycolic acid treatments increase fibroblasts’ production of collagen in vivo (in hairless mice) and in vitro (in human skin fibroblast culture) better than either lactic acid or malic acid. However, if you’re deciding between prescription-strength retinoids and over-the-counter glycolic acid peels, you may want to choose the prescription retinoid cream. According to a randomized, placebo-controlled double-blind study, it was found that 0.05% all-trans-retinoic acid was more effective than 10% glycolic acid (a concentration found in at-home treatments) in treating signs of aging.

5. Topical Ascorbyl Palmitate Vitamin C Treatments
According to a review in the International Journal of Pharmaceutics, vitamin C triggers collagen production and thereby increasing skin firmness. Dr. Jeannette Graf also adds in Dr. Burgess’s Cosmetic Dermatology text, “Topical vitamin C increases levels of tissue inhibitors of collagen-degrading matrix metalloproteinases (MMP-1).” Vitamin C is particularly potent in conjunction with vitamin E; unfortunately, a 2008 Dermatology Therapy study cited in Best Life magazine found that very few products containing these vitamins remain effective. This is most likely because vitamin C becomes esterified and inactive upon exposure to light, air, and heat. Your best bet? Keep your vitamin C and E product tightly sealed and in a cool, dark place, or consider a stabilized form of vitamin C, although less research has been done on the effects of, say, 2% ascorbyl palmitate than 15% L-ascorbic acid.

6. Topical Peptide Treatments
Palmitoyl pentapeptide-3 has been shown to stimulate feedback regulation of new collagen synthesis and to result in an increased production of extracellular matrix proteins (collagen types I and II and fibronectin). For these reasons, palmitoyl pentapeptide-3 is increasingly popular in skin care products.

Palmitoyl oligopeptide is a second sequence of collagen-stimulating peptides. A 2007 study in Dermatologic Therapy suggests that palmitoyl oligopeptide significantly stimulates human skin collagen production in fibroblasts, which may slow the degradation of collagen over time.

7. Treatments with Collagen in the Ingredients
Collagen in skin care products acts as only a superior moisturizing ingredient. Topically applying collagen has never been shown to stimulate collagen synthesis or growth. This is because, according to Dr. Leslie Baumann in Cosmetic Dermatology, topically applied collagen is too large to fit through the stratum corneum (uppermost layer of the skin), as collagens have a molecular weight of 15000 to 50000 daltons, whereas only molecules of molecular weight 5000 or less can typically penetrate the skin.

8. Prevent Future Collagen Loss!
Don’t smoke. Wear sunscreen everyday and limit UV exposure. Eat - and topically apply - lots of anti-oxidants, which has been shown to be more effective than either method alone. Use retinoids or alpha hydroxy acids to increase cell turnover. And exercise - although the link between exercise and skin’s collagen production is only implied, always remember, what’s good for your health is good for your skin.


If you're like most people, you probably understand that collagen loss leads to aging skin and for that reason you need to use our skin care serum that contains collagen stimulating actives in order to combat its loss. It's important to understand that rubbing collagen into your skin is not going to prevent its loss. In order to combat the loss of collagen, you need to learn how to naturally produce collagen by using products that contain certain active ingredients. It might sound like a difficult task to naturally produce collagen protein. However, it is actually quite simple. A select few ingredients are known to stop the loss of collagen and elastin and stimulate their re-growth naturally. Here are the active ingredients that your skin needs in order to combat collagen loss.

1. Keratin
Hands down the best ingredient available for stimulating the collagen production in your skin. Keratin is a protein found throughout the body, which has an important structural role in the skin. The ability to convert natural keratin into a functional form that is readily-available to the skin is a recent breakthrough. This is a new exciting, cutting edge substance. Bioactive Keratin actually stimulates your own collagen to grow again. In fact, it is proven in clinical trials to stimulate not only the regrowth of collagen but also elastin, thereby promoting firmness and elasticity. In short, fewer wrinkles, and more youthful, healthier looking skin. It may help improve your skin's ability to retain its needed natural moisture.

Indeed, studies show a sustained 14% improvement in skin moisture retention over 18 days. Studies also show a sustained improvement in skin elasticity of 42% over 18 days. Bioactive Keratin penetrates your skin deeply and creates an invisible barrier that protects your skin and locks moisture in, which scientific studies show stimulates the production of new skin cells. Keratin stops the loss of collagen and stimulates its production. It also stimulates the production of elastin, another vital protein in the skin.

2. Active Manuka Honey
A special honey from New Zealand has unique healing properties. It has been used in skin care for centuries by the Maori people of New Zealand and it's easy to understand why. When used topically, Active Manuka Honey can restore and rejuvenate your skin. It supports the skin cell renewal process and assists in the formation of stronger collagen protein. As an added benefit, active manuka honey is rich in antioxidants and helps to reduce blemishes.

3. Avocado Oil If you want to know how to naturally produce collagen, you need to use face masks or creams that contain avocado oil. Avocado oil is deeply hydrating and highly compatible with the natural oils in your skin. Avocado oil is high in plant steroids, which help to reduce blemishes and age spots. It also helps to regenerate and rejuvenate skin damaged by free radicals. Avocado oil is important because it is scientifically proven to stimulate collagen production and it increases the proportion of soluble collagen in the dermis of your skin.

4. Wakame Sea Kelp
Wakame sea kelp extract is an exotic kelp native to the Japanese Sea, which raises the levels of hyaluronic acid in your skin by stopping the enzyme that is breaking it down. This increase will act to greatly smooth out many of the lines on your face. It works by blocking a harmful enzyme in your body called hyaluronidase. Hyaluronidase breaks down hyaluronic acid in your skin. You may think "well who cares." Well, you should because without hyaluronic acid, the elastin and collagen fibers lose their "glue," which leads to a loss of youthful appearance and dark eye circles. If you research this on Wikipedia, you will read, for example, "Hyaluronan is also a major component of skin, where it is involved in tissue repair."

5. CoEnzyme Q-10, Idebenone, Ubiquinone
In the 1970s and 1980s, researchers had been studying the potential of Coenzyme Q10 (CoQ10) to reduce free radical damage. A vitamin-like natural compound found in all aerobic organisms, it plays an important role in cellular energy production and is also an effective antioxidant. Trying to boost CoQ10's therapeutic effects, scientists synthesized and tested a variety of its chemical analogs and derivatives. Most of these derivatives were found ineffective or unsafe. However, one of the few exceptions was idebenone. It is closely related to CoQ10 in its structure. However, Idebenone is more effective than CoQ10 in protecting cells from the free radical damage resulting from reduced blood flow. The benefits of this ingredient include shielding skin from environmental damage, improving the appearance of fine lines and wrinkles, and reducing dryness and smoothing skin texture. If you look at the ingredient list for some of the better skin care products, you'll often see CoQ10 listed. CoQ10 is short for Coenzyme Q10, so you may also see it listed this way. CoQ10 is a vitamin like substance that is found in all of our body's cells and is very important for healthy skin. CoQ10 is a powerful anti-oxidant. A lot of skin damage and aging comes from free radicals wreaking havoc in our body's cells. CoQ10's anti-oxidant ability can counter these free radicals before damage occurs. Unfortunately, like many other vital substances, as we age, the amount of CoQ10 in our bodies becomes depleted. CoQ10 can penetrate deeply, it is extremely effective at ‘gobbling up’ free radicals in your skin. The result is a powerful anti-wrinkle effect, and can also promote collagen and elastin production as well. Together, these main active ingredients are some of the most powerful anti-aging skin care compounds available, and can significantly improve the look and feel of your skin. As you can see, it is possible to stop the loss of collagen protein in your skin, you can stimulate its re-growth. The result will be more youthful skin with improved elasticity, firmness, and tone. You will also notice a dramatic reduction in wrinkles and fine lines. Within days of using this serum, you will see a dramatic difference in the way your skin looks and feels by learning how to naturally produce collagen. So toss those "collagen" creams out and start using our CP Serum for a skin care product that will actually help you re-grow the collagen you have lost!

Idebenone is a Superceutical for The Next Level of Skin Rejuvenation and Free Radical Protection

What is it? Idebenone is the bioengineered cousin of the vital human antioxidant enzyme - CoEnzyme Q10 - but its 60% smaller (so it penetrates the skin) and up to 1000x more effective, simply put its "Super CoQ10".

How does it work? It targets aging at the cellular source - the mitochondria where it helps to revitalize the skin's cells by eliminating excess free radical formation that results from the way cells make energy - in effect it corrects the essence of cellular aging.

How is it unique? Unlike vitamin and botanical antioxidants, Idebenone is a respiratory chain antioxidant, a totally new kind of antioxidant, which can correct the signs of aging and also offers the highest protection against harmful environmental free radical stress with an Environmental Protection Factor of EPF 95, the highest rating of all antioxidants tested.

Why should I use it? Idebenone delivers a whole new level of skin rejuvenation that you cannot get from AHA, Vitamin A, Vitamin C or other cosmeceuticals because of its absolutely unique mode of action. If you have reached a plateau with your current skin care regimen and want the highest level of skin rejuvenation you can only get this from Idebenone the Superceutical.

Idebenone delivers multiple anti-aging benefits: • Helps prevent skin aging at its cellular source • Decreases the appearance of fine lines and wrinkles • Improves uneven skin tone and texture • Brightens the look of skin • Reduces the appearance of unwanted pigmentation • Offers maximum protection against environmental stress – EPF 95

6. Alpha Lipoic Acid
Lipoic acid is the strongest and longest lasting antioxidant. Lipoic Acid is both water-soluble and oil-soluble. Extremely powerful antioxidant that helps Vitamins C and E work more effectively in the skin. 400 times more powerful than Vitamin C as an antioxidant. Increases gluathione, the body's most important antioxidant. Powerful anti-inflammatory. It has anti-inflammatory qualities, which can be helpful in reducing the redness associated with rosacea, acne and sensitive skin types. It reduces the appearance of wrinkles, fine lines, dull skin, puffy eyes, and dark circles. This means it can fight free radicals in any part of a cell (intracellular) as well as the spaces in between the cells (intercellular). Lipoic acid increases the cell's metabolism, which allows the cell to take in more nutrients, eliminate more wastes, and replace more damaged components. It increases the free radical fighting properties of other antioxidants. Lipoic acid activates the transcription factor AP-1 that produces collagen-digesting enzymes that digest damaged collagen. Damaged collagen is responsible for wrinkles and scars so eliminating the damaged collagen can reverse aging. Lipoic acid is credited with reducing under-eye puffiness, sallow skin, enlarged pores, redness, lines, wrinkles, and acne scars.